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An IFR clearance is required when operating in Class A airspace, regardless of weather conditions. Class A airspace begins at 18,000 feet MSL and extends up to and including 60,000 feet MSL, and it is exclusively for IFR operations. Pilots operating in this airspace must always adhere to IFR regulations and maintain appropriate separation from other aircraft, which is critical for safety in the highly congested and complex environments typically found above 18,000 feet.

Other scenarios, such as operating in Class E airspace, above 14,500 feet, or at night, do not universally require an IFR clearance under VFR conditions. For example, VFR operations can occur in Class E airspace without needing an IFR clearance if the weather conditions allow. Similarly, flying at night or above 14,500 feet can be conducted under VFR as long as the pilot maintains visual reference and complies with VFR requirements. However, once a pilot enters Class A airspace, IFR clearance is mandatory.